Gastroprotective effect of leaf extract of two varieties grapevine (Vitis vinifera L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats.
Identifieur interne : 000063 ( Main/Exploration ); précédent : 000062; suivant : 000064Gastroprotective effect of leaf extract of two varieties grapevine (Vitis vinifera L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats.
Auteurs : Nabil Saadaoui [Tunisie] ; Asma Weslati [Tunisie] ; Taha Barkaoui [Tunisie] ; Ikram Khemiri [Tunisie] ; Wafa Gadacha [Tunisie] ; Abdelaziz Souli [Tunisie] ; Moncef Mokni [Tunisie] ; Mounira Harbi [Tunisie] ; Mossadok Ben-Attia [Tunisie]Source :
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [ 1366-5804 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antioxydants (isolement et purification), Antioxydants (pharmacologie), Antiulcéreux (isolement et purification), Antiulcéreux (pharmacologie), Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Feuilles de plante (composition chimique), Feuilles de plante (croissance et développement), Modèles animaux de maladie humaine (MeSH), Muqueuse gastrique (anatomopathologie), Muqueuse gastrique (effets des médicaments et des substances chimiques), Muqueuse gastrique (métabolisme), Mâle (MeSH), Rat Wistar (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Tunisie (MeSH), Ulcère gastrique (anatomopathologie), Ulcère gastrique (induit chimiquement), Ulcère gastrique (métabolisme), Ulcère gastrique (prévention et contrôle), Vitis (composition chimique), Vitis (croissance et développement), Éthanol (MeSH).
- MESH :
- anatomopathologie : Muqueuse gastrique, Ulcère gastrique.
- composition chimique : Feuilles de plante, Vitis.
- croissance et développement : Feuilles de plante, Vitis.
- effets des médicaments et des substances chimiques : Muqueuse gastrique, Stress oxydatif.
- induit chimiquement : Ulcère gastrique.
- isolement et purification : Antioxydants, Antiulcéreux, Extraits de plantes.
- métabolisme : Muqueuse gastrique, Ulcère gastrique.
- pharmacologie : Antioxydants, Antiulcéreux, Extraits de plantes.
- prévention et contrôle : Ulcère gastrique.
- Animaux, Modèles animaux de maladie humaine, Mâle, Rat Wistar, Tunisie, Éthanol.
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Ulcer Agents (isolation & purification), Anti-Ulcer Agents (pharmacology), Antioxidants (isolation & purification), Antioxidants (pharmacology), Disease Models, Animal (MeSH), Ethanol (MeSH), Gastric Mucosa (drug effects), Gastric Mucosa (metabolism), Gastric Mucosa (pathology), Male (MeSH), Oxidative Stress (drug effects), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Plant Leaves (chemistry), Plant Leaves (growth & development), Rats, Wistar (MeSH), Stomach Ulcer (chemically induced), Stomach Ulcer (metabolism), Stomach Ulcer (pathology), Stomach Ulcer (prevention & control), Tunisia (MeSH), Vitis (chemistry), Vitis (growth & development).
- MESH :
- chemical , isolation & purification : Anti-Ulcer Agents, Antioxidants, Plant Extracts.
- chemical , pharmacology : Anti-Ulcer Agents, Antioxidants, Plant Extracts.
- geographic : Tunisia.
- chemically induced : Stomach Ulcer.
- chemistry : Plant Leaves, Vitis.
- drug effects : Gastric Mucosa, Oxidative Stress.
- growth & development : Plant Leaves, Vitis.
- metabolism : Gastric Mucosa, Stomach Ulcer.
- pathology : Gastric Mucosa, Stomach Ulcer.
- prevention & control : Stomach Ulcer.
- Animals, Disease Models, Animal, Ethanol, Male, Rats, Wistar.
Abstract
Context:Vitis vinifera leaves are traditionally used in Tunisian folk medicine to treat digestive pathologies.Objective: We aimed to compare the gastroprotective effects of hydromethanolic leaves extracts of wild and cultivated grapes accessions native of Tunisia.Materials and methods: The phytochemical analysis of grapevine leaves extracts was performed. The gastroprotective activity was evaluated by ethanol-induced gastric-ulcer in rats pre-treated with increased doses of the extracts or with the standard omeprazole. Index of gastric secretions (volume, pH and gastric mucus production), stomach wall histology and biochemical parameters were estimated for assessment of anti-secretory and gastroprotective effects of the extracts.Results: Pre-treatment with grapevine leaves extracts decreased significantly gastric volume, gastric mucosal damage and increased significantly gastric juice pH compared with the negative control group. The extracts prevented ethanol-induced decrease of the activity of antioxidant enzymes while the levels of malondialdehyde and of reduced glutathione were decreased significantly. Moreover, the most marked effect was observed at low doses of wild ecotype 'Nefza-I' extracts.Conclusion: The leaves of Vitis species might be suitable as a functional food for therapeutic purpose and demonstrates gastroprotective action in gastric lesions model. Both accessions exhibited gastroprotective effects, but wild 'Nefza-I' ecotype was more effective than cultivar 'Marsaoui'.
DOI: 10.1080/1354750X.2019.1691266
PubMed: 31714159
Affiliations:
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University of Carthage, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Souli, Abdelaziz" sort="Souli, Abdelaziz" uniqKey="Souli A" first="Abdelaziz" last="Souli">Abdelaziz Souli</name><affiliation wicri:level="1"><nlm:affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Mokni, Moncef" sort="Mokni, Moncef" uniqKey="Mokni M" first="Moncef" last="Mokni">Moncef Mokni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Pathological Cytology, Farhat Hached University Hospital, Sousse University, Sousse, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Anatomy and Pathological Cytology, Farhat Hached University Hospital, Sousse University, Sousse</wicri:regionArea><wicri:noRegion>Sousse</wicri:noRegion></affiliation></author><author><name sortKey="Harbi, Mounira" sort="Harbi, Mounira" uniqKey="Harbi M" first="Mounira" last="Harbi">Mounira Harbi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Horticulture, National Institute of Agricultural Research of Tunisia, INRAT, Ariana, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Horticulture, National Institute of Agricultural Research of Tunisia, INRAT, 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xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Weslati, Asma" sort="Weslati, Asma" uniqKey="Weslati A" first="Asma" last="Weslati">Asma Weslati</name><affiliation wicri:level="1"><nlm:affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Barkaoui, Taha" sort="Barkaoui, Taha" uniqKey="Barkaoui T" first="Taha" last="Barkaoui">Taha Barkaoui</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry and Molecular Biology, Research Unit (UR17ES20), Faculty of Sciences of Bizerta, Carthage University, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Biochemistry and Molecular Biology, Research Unit (UR17ES20), Faculty of Sciences of Bizerta, Carthage University, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Khemiri, Ikram" sort="Khemiri, Ikram" uniqKey="Khemiri I" first="Ikram" last="Khemiri">Ikram Khemiri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Gadacha, Wafa" sort="Gadacha, Wafa" uniqKey="Gadacha W" first="Wafa" last="Gadacha">Wafa Gadacha</name><affiliation wicri:level="1"><nlm:affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Souli, Abdelaziz" sort="Souli, Abdelaziz" uniqKey="Souli A" first="Abdelaziz" last="Souli">Abdelaziz Souli</name><affiliation wicri:level="1"><nlm:affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Mokni, Moncef" sort="Mokni, Moncef" uniqKey="Mokni M" first="Moncef" last="Mokni">Moncef Mokni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Pathological Cytology, Farhat Hached University Hospital, Sousse University, Sousse, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Anatomy and Pathological Cytology, Farhat Hached University Hospital, Sousse University, Sousse</wicri:regionArea><wicri:noRegion>Sousse</wicri:noRegion></affiliation></author><author><name sortKey="Harbi, Mounira" sort="Harbi, Mounira" uniqKey="Harbi M" first="Mounira" last="Harbi">Mounira Harbi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Horticulture, National Institute of Agricultural Research of Tunisia, INRAT, Ariana, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Horticulture, National Institute of Agricultural Research of Tunisia, INRAT, Ariana</wicri:regionArea><wicri:noRegion>Ariana</wicri:noRegion></affiliation></author><author><name sortKey="Ben Attia, Mossadok" sort="Ben Attia, Mossadok" uniqKey="Ben Attia M" first="Mossadok" last="Ben-Attia">Mossadok Ben-Attia</name><affiliation wicri:level="1"><nlm:affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna</wicri:regionArea><wicri:noRegion>Zarzouna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals</title><idno type="eISSN">1366-5804</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Ulcer Agents (isolation & purification)</term><term>Anti-Ulcer Agents (pharmacology)</term><term>Antioxidants (isolation & purification)</term><term>Antioxidants (pharmacology)</term><term>Disease Models, Animal (MeSH)</term><term>Ethanol (MeSH)</term><term>Gastric Mucosa (drug effects)</term><term>Gastric Mucosa (metabolism)</term><term>Gastric Mucosa (pathology)</term><term>Male (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Plant Extracts (isolation & purification)</term><term>Plant Extracts (pharmacology)</term><term>Plant Leaves (chemistry)</term><term>Plant Leaves (growth & development)</term><term>Rats, Wistar (MeSH)</term><term>Stomach Ulcer (chemically induced)</term><term>Stomach Ulcer (metabolism)</term><term>Stomach Ulcer (pathology)</term><term>Stomach Ulcer (prevention & control)</term><term>Tunisia (MeSH)</term><term>Vitis (chemistry)</term><term>Vitis (growth & development)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antioxydants (isolement et purification)</term><term>Antioxydants (pharmacologie)</term><term>Antiulcéreux (isolement et purification)</term><term>Antiulcéreux (pharmacologie)</term><term>Extraits de plantes (isolement et purification)</term><term>Extraits de plantes (pharmacologie)</term><term>Feuilles de plante (composition chimique)</term><term>Feuilles de plante (croissance et développement)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Muqueuse gastrique (anatomopathologie)</term><term>Muqueuse gastrique (effets des médicaments et des substances chimiques)</term><term>Muqueuse gastrique (métabolisme)</term><term>Mâle (MeSH)</term><term>Rat Wistar (MeSH)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Tunisie (MeSH)</term><term>Ulcère gastrique (anatomopathologie)</term><term>Ulcère gastrique (induit chimiquement)</term><term>Ulcère gastrique (métabolisme)</term><term>Ulcère gastrique (prévention et contrôle)</term><term>Vitis (composition chimique)</term><term>Vitis (croissance et développement)</term><term>Éthanol (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Anti-Ulcer Agents</term><term>Antioxidants</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Ulcer Agents</term><term>Antioxidants</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Muqueuse gastrique</term><term>Ulcère gastrique</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Stomach Ulcer</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plant Leaves</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Feuilles de plante</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Feuilles de plante</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gastric Mucosa</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Muqueuse gastrique</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plant Leaves</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Ulcère gastrique</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antioxydants</term><term>Antiulcéreux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gastric Mucosa</term><term>Stomach Ulcer</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Muqueuse gastrique</term><term>Ulcère gastrique</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gastric Mucosa</term><term>Stomach Ulcer</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term><term>Antiulcéreux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Stomach Ulcer</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Ulcère gastrique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Ethanol</term><term>Male</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Rat Wistar</term><term>Tunisie</term><term>Éthanol</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b>Context:</b><i>Vitis vinifera</i> leaves are traditionally used in Tunisian folk medicine to treat digestive pathologies.<b>Objective:</b> We aimed to compare the gastroprotective effects of hydromethanolic leaves extracts of wild and cultivated grapes accessions native of Tunisia.<b>Materials and methods:</b> The phytochemical analysis of grapevine leaves extracts was performed. The gastroprotective activity was evaluated by ethanol-induced gastric-ulcer in rats pre-treated with increased doses of the extracts or with the standard omeprazole. Index of gastric secretions (volume, pH and gastric mucus production), stomach wall histology and biochemical parameters were estimated for assessment of anti-secretory and gastroprotective effects of the extracts.<b>Results:</b> Pre-treatment with grapevine leaves extracts decreased significantly gastric volume, gastric mucosal damage and increased significantly gastric juice pH compared with the negative control group. The extracts prevented ethanol-induced decrease of the activity of antioxidant enzymes while the levels of malondialdehyde and of reduced glutathione were decreased significantly. Moreover, the most marked effect was observed at low doses of wild ecotype 'Nefza-I' extracts.<b>Conclusion:</b> The leaves of <i>Vitis</i> species might be suitable as a functional food for therapeutic purpose and demonstrates gastroprotective action in gastric lesions model. Both accessions exhibited gastroprotective effects, but wild 'Nefza-I' ecotype was more effective than cultivar 'Marsaoui'.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31714159</PMID><DateCompleted><Year>2020</Year><Month>06</Month><Day>01</Day></DateCompleted><DateRevised><Year>2020</Year><Month>06</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1366-5804</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals</Title><ISOAbbreviation>Biomarkers</ISOAbbreviation></Journal><ArticleTitle>Gastroprotective effect of leaf extract of two varieties grapevine (<i>Vitis vinifera</i> L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats.</ArticleTitle><Pagination><MedlinePgn>48-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/1354750X.2019.1691266</ELocationID><Abstract><AbstractText><b>Context:</b><i>Vitis vinifera</i> leaves are traditionally used in Tunisian folk medicine to treat digestive pathologies.<b>Objective:</b> We aimed to compare the gastroprotective effects of hydromethanolic leaves extracts of wild and cultivated grapes accessions native of Tunisia.<b>Materials and methods:</b> The phytochemical analysis of grapevine leaves extracts was performed. The gastroprotective activity was evaluated by ethanol-induced gastric-ulcer in rats pre-treated with increased doses of the extracts or with the standard omeprazole. Index of gastric secretions (volume, pH and gastric mucus production), stomach wall histology and biochemical parameters were estimated for assessment of anti-secretory and gastroprotective effects of the extracts.<b>Results:</b> Pre-treatment with grapevine leaves extracts decreased significantly gastric volume, gastric mucosal damage and increased significantly gastric juice pH compared with the negative control group. The extracts prevented ethanol-induced decrease of the activity of antioxidant enzymes while the levels of malondialdehyde and of reduced glutathione were decreased significantly. Moreover, the most marked effect was observed at low doses of wild ecotype 'Nefza-I' extracts.<b>Conclusion:</b> The leaves of <i>Vitis</i> species might be suitable as a functional food for therapeutic purpose and demonstrates gastroprotective action in gastric lesions model. Both accessions exhibited gastroprotective effects, but wild 'Nefza-I' ecotype was more effective than cultivar 'Marsaoui'.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Saadaoui</LastName><ForeName>Nabil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weslati</LastName><ForeName>Asma</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barkaoui</LastName><ForeName>Taha</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Biochemistry and Molecular Biology, Research Unit (UR17ES20), Faculty of Sciences of Bizerta, Carthage University, Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khemiri</LastName><ForeName>Ikram</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gadacha</LastName><ForeName>Wafa</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souli</LastName><ForeName>Abdelaziz</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mokni</LastName><ForeName>Moncef</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Pathological Cytology, Farhat Hached University Hospital, Sousse University, Sousse, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harbi</LastName><ForeName>Mounira</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Horticulture, National Institute of Agricultural Research of Tunisia, INRAT, Ariana, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Attia</LastName><ForeName>Mossadok</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5368-4800</Identifier><AffiliationInfo><Affiliation>Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biomarkers</MedlineTA><NlmUniqueID>9606000</NlmUniqueID><ISSNLinking>1354-750X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000897">Anti-Ulcer Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>3K9958V90M</RegistryNumber><NameOfSubstance UI="D000431">Ethanol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000897" MajorTopicYN="N">Anti-Ulcer Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005753" MajorTopicYN="N">Gastric Mucosa</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018515" MajorTopicYN="Y">Plant Leaves</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013276" MajorTopicYN="N">Stomach Ulcer</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014416" MajorTopicYN="N" Type="Geographic">Tunisia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027843" MajorTopicYN="Y">Vitis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Vitis vinifera L.</Keyword><Keyword MajorTopicYN="N">antioxidant activity</Keyword><Keyword MajorTopicYN="N">gastroprotection</Keyword><Keyword MajorTopicYN="N">hydromethanolic extract</Keyword><Keyword MajorTopicYN="N">leaves</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31714159</ArticleId><ArticleId IdType="doi">10.1080/1354750X.2019.1691266</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Tunisie</li></country><region><li>Gouvernorat de Tunis</li></region><settlement><li>Tunis</li></settlement></list><tree><country name="Tunisie"><noRegion><name sortKey="Saadaoui, Nabil" sort="Saadaoui, Nabil" uniqKey="Saadaoui N" first="Nabil" last="Saadaoui">Nabil Saadaoui</name></noRegion><name sortKey="Barkaoui, Taha" sort="Barkaoui, Taha" uniqKey="Barkaoui T" first="Taha" last="Barkaoui">Taha Barkaoui</name><name sortKey="Ben Attia, Mossadok" sort="Ben Attia, Mossadok" uniqKey="Ben Attia M" first="Mossadok" last="Ben-Attia">Mossadok Ben-Attia</name><name sortKey="Gadacha, Wafa" sort="Gadacha, Wafa" uniqKey="Gadacha W" first="Wafa" last="Gadacha">Wafa Gadacha</name><name sortKey="Harbi, Mounira" sort="Harbi, Mounira" uniqKey="Harbi M" first="Mounira" last="Harbi">Mounira Harbi</name><name sortKey="Khemiri, Ikram" sort="Khemiri, Ikram" uniqKey="Khemiri I" first="Ikram" last="Khemiri">Ikram Khemiri</name><name sortKey="Mokni, Moncef" sort="Mokni, Moncef" uniqKey="Mokni M" first="Moncef" last="Mokni">Moncef Mokni</name><name sortKey="Souli, Abdelaziz" sort="Souli, Abdelaziz" uniqKey="Souli A" first="Abdelaziz" last="Souli">Abdelaziz Souli</name><name sortKey="Weslati, Asma" sort="Weslati, Asma" uniqKey="Weslati A" first="Asma" last="Weslati">Asma Weslati</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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